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Hepatic biotransformation

Hepatic biotransformation, one of the main pillars to take into account when carrying out a process detox real, deep and effective

Our large laboratory exclusively performs a series of biochemical steps that are essential for eliminating toxins.

If your liver does not have enough substances (vitamins, minerals, amino acids, etc.) to perform its detoxifying functions, it will be very difficult to eliminate toxins and heavy metals.

It will be of little use to do fasts, semi-fasts, therapies detox of juices and broths, or that you follow any strategy detox Of those currently on the market, if a single nutrient is missing in this biotransformation, you will not detoxify anything.

Hepatic biotransformation is a process that allows us to eliminate toxins.

This process basically consists of two stages:


PHASE 1. Hydroxylation

For a toxin to be eliminated, an essential condition is that it is soluble in water.

The problem with xenobiotics (substances foreign to the body) is that they are highly soluble in fat.

In this phase, the liver tries to transform liposoluble toxins (soluble in fat) into hydrosoluble toxins (soluble in water), combining them with a group of enzymes called cytochrome P450.

We can think of enzymes as workers on an assembly line, and the function of that line would be to carry out a chemical reaction. These workers need tools, cofactors, which are nutrients like vitamins and minerals, and all of this happens through hydroxylation reactions.

Hydroxylation is a chemical reaction in which a hydroxyl group (OH) is introduced into a compound by replacing a hydrogen atom, which oxidizes the compound.

This process generates a large amount of free radicals that can damage cellular DNA.

To avoid this we must provide substances/nutrients with high antioxidant capacity.

Nutrients and cofactors needed to support phase 1:

  • B vitamins

  • amino acids (glutamine, N-acetylcysteine, glycine)

  • flavonoids

  • vitamin C

  • carotenoids

  • vitamin E

  • selenium

  • zinc

  • copper

  • manganese

  • coenzyme Q10

  • R-Lipoic acid

  • NADH

  • silymarin (milk thistle)

  • cynarina (artichoke)

  • curcumin (turmeric)

  • sinigrina (Lepidium Latifolium)

  • chlorella algae

  • indole-3-carbinol and sulforaphane (cruciferous vegetables)

  • transresveratrol (red grapes and berries)

PHASE 2. Conjugation

Unlike phase 1, where we stimulate the expression of different enzymes to transform the toxic substance, the reactions of phase 2 decrease the biological activity and the toxicity of the original molecule.

Conjugation reactions occur, which are based on uniting the metabolic products of the transformation of xenobiotics in phase I with compounds that will neutralize them.

We could say that they put them in secure containers for disposal.

Main reactions:

  • glucuronidation conjugation

  • sulfate conjugation

  • glutathione conjugation

  • amino acid conjugation

  • acetylation

  • methylation

Glucuronidation

Most important conjugation reaction. Responsible for the conjugation of 40% of drugs that pass through phase 2.

This reaction is mediated by an enzyme called uridine diphosphate glucuronosyl-transferase (UGT).

In this way we have to eliminate bilirubin, estrogens, androgens (testosterone, DHEA), T4 and T3, benzodiazepines, mycotoxins and fat-soluble vitamins

Some clues that this pathway is working too slowly could be excess androgens in women (acne, oily skin, excess facial hair, alopecia, ingrown hairs), unexplained itching all over the body, yellowing of the sclera of the eyes, or having Gilbert's syndrome (an analysis would show elevated levels of unconjugated bilirubin).

We can increase the activity of this enzyme thanks to the glucuronic acid present in tea. kombucha , as well as in supplements (glucuronalactone, magnesium, NADH, Transresveratrol, dandelion, bioflavonoids).

Sulfation

It is responsible for 20% of phase 2 reactions.

Detoxifies xenobiotics (BPA, triclosan, benoxophenone-3, BHT, xylenol, etc.), catecholamines (adrenaline, noradrenaline), steroid and thyroid hormones (T4, T3, estrogen, progesterone, DHEA, melatonin), bile acids and paracetamol, as well as tyramine from cheese or phenylethylamine from cocoa.

The raw material for sulfation, as you might have guessed, is sulfate.

Where do we get sulfate from?

There are mainly two routes: from the amino acids cysteine, taurine and methionine and, by direct absorption, from the intestine.

Molybdenum, vitamin B2, B3 and magnesium are also involved , since they are the cofactors needed by the enzyme responsible for transforming sulfites into sulfates (SUOX-sulfite oxidase)

It will be important to consume enough quality protein and also foods rich in sulfur such as eggs, cruciferous vegetables (broccoli, cabbage, kale, cauliflower, kohlrabi, etc.) and allspice (garlic, leeks and onions).

An enzyme called sulfite oxidase (SUOX) catalyzes the transformation of sulfite to sulfate, a reaction that is necessary for the metabolism of sulfur-containing amino acids (methionine and cysteine).

For the body to transform sulfites into sulfates we will need several cofactors which are molybdenum, magnesium, B3 and riboflavin or vitamin B2.

We find molybdenum in foods such as lentils, azuki beans , buckwheat, pumpkin seeds, and dark green leafy vegetables.

Some interesting sources of riboflavin are kefir, eggs, salmon, and almonds.

Foods such as cocoa, nuts, wheat bran, pumpkin seeds, and legumes are rich in magnesium.

Glutathione

Glutathione, aside from its ability to bind to various toxins and completely inactivate them, is a potent antioxidant, so it actually supports both phase 1 and phase 2.

The reaction is catalyzed by glutathione-S-transferase and glutathione itself is the cofactor.

To promote glutathione synthesis we need precursors and cofactors such as:

  • The amino acids cysteine , glycine and glutamine ;

  • alpha lipoic acid (organic organ meats such as liver and kidneys, spinach and broccoli);

  • magnesium (dark green leafy cereals, cocoa and nuts);

  • selenium (Brazil nuts, alliaceous and cruciferous vegetables);

  • vitamin B3 ( eggs, meats, oily fish, nutritional yeast, peanuts; legumes);

  • vitamin B6 (wild salmon, chicken, turkey, potato, avocado, spinach, banana).

The vast majority of diseases classified as chronic are associated with glutathione deficiency, so increasing glutathione levels should be the starting point in these types of situations.

Higher levels of glutathione equate to a greater ability to combat oxidative stress and toxic load.

Aminoacidation

Type of reaction in which an amino acid is added to the compound to be deactivated.

There are several types of amino acid conjugation that take place in this phase 2.

The main amino acid of this pathway is taurine , which is responsible for producing bile acids such as taurocholic acid.

Another important amino acid in this reaction is glycine , which helps produce glycocholic acid and contributes to improving bile production, since one of the salts is formed with this amino acid.

These amino acids are used in this pathway preferably to conjugate benzoate, salicylate toluene.

Certain medications, such as aspirin and NSAIDs (nonsteroidal anti-inflammatory drugs), which are currently in common use, must be monitored to prevent this pathway from being affected by the effects of these substances.

We must also monitor other substances that are present in our lives directly or indirectly:

Food colorings such as E110 (yellow coloring) or E122 (red coloring).

Chemicals found in paints, nail polish, stain removers, perfumes, cosmetics, sunscreen, glues, and preservatives such as sodium benzoate (which can be converted into benzene, a carcinogenic molecule).

It is very important in this pathway to obtain sufficient amounts of taurine and glycine so that all these substances we mention here can be metabolized and eliminated.

We find taurine and glycine mainly in foods of animal origin (meat, fish, eggs, dairy products).

Octopus and red seaweed (such as dulse and nori) are also rich sources of taurine.

What can we do to improve aminoacidation at the orthomolecular level? Simple: provide taurine , glycine and NADH .

Acetylation

Acetylation is a reaction that introduces an acetyl group into a chemical compound and the enzyme that handles this is N-acetyl transferase, whose cofactors are vitamin B2 or riboflavin, the vitamin B5 or pantothenic acid (viscera, chicken, fish, seafood, eggs, broccoli, avocado, legumes, mushrooms, kefir), vitamin C or ascorbic acid (acerola, kiwi, oranges, strawberries, broccoli, red pepper) and acetyl-CoA.

Helps eliminate the following toxins: caffeine, benzodiazepines, histamine and aromatic amines.

What can we do to improve acetylation at the orthomolecular level? It's also simple: provide: vitamin C , B vitamins, as well as Acetyl-L-carnitine , since it will offer a greater number of acetyl groups when released from carnitine.

Methylation

This process called methylation is involved in many biochemical processes, one of which is detoxification.

The reaction it carries out involves the transfer of a methyl group, catalyzed by a family of enzymes called methyltransferases. The methyl group-donating compound is SAMe (S-adenosylmethionine), which comes from the essential amino acid methionine.

It is important to know what SAMe is and where it comes from, since it provides almost all of the methyl groups used in toxin conjugation.

More SAMe equals more effective detoxification.

The substances processed in this pathway are estrogens, catecholamines (adrenaline, noradrenaline, dopamine), heavy metals, histamine, aromatic amines, etc.

There's something very important that I've been saying for years: a person's genetic makeup predisposes them to certain problems in the expression of their genes, in this case, regarding methylation.

There's a very simplistic view of this. If you develop a genetic polymorphism, the conclusion—from the conventional perspective—is that you'll always have methylation problems; but that's not the case.

Genes show us our genetic predisposition (which doesn't even reach 20%), but what's important is the phenotypic expression, which can be modulated by any external or internal factor: nutrients, toxic substances, exercise, stress, and, in general, any aspect that has to do with your lifestyle habits.

Epigenetics is the key to preventing even a genetic polymorphism from affecting you.

What can be done to improve methylation?

I'll make it easy for you:

  • Avoid all those components that behave as methylation inhibitors (antibiotics, contraceptives, antacids).

  • You will also benefit from increasing your intake of foods rich in vitamin B9, vitamin B12, and choline to improve the methylcobalamin and betaine pathways (meat, fish, eggs, quality dairy products, green leafy vegetables, broccoli, Brussels sprouts, peanuts, etc.).

  • Provides supplements rich in: vitamin B9 (methylfolate), vitamin B12 (methylcobalamin), trimethylglycine, choline, vitamin B2, vitamin B3, vitamin B6, magnesium...

As you may have noticed, eliminating toxins and heavy metals is an incredible journey, involving countless nutrients and substances, without which the journey would not reach its destination (outside the body).

That is why it is important to keep this in mind before any treatment/therapy or process. detox , because if we don't do things correctly at the micronutritional level, we won't be able to detoxify, and we may even worsen our health.

To carry out a real, deep, and effective detox process, we must provide all of the substances I've mentioned, since they are what will allow metabolic pathways to be efficient and thus eliminate any type of internal toxin.

There will be no heavy metal or toxic non-metal that can resist being eliminated if you provide each and every one of the substances that are part of these cellular processes.

The difficult part is finding all these substances, both through food and supplementation.

This is what I've encountered over the more than 15 years I've been a therapist: it's difficult to provide all the substances and nutrients our phases I and II liver need through diet and supplementation.

Today's diet provides us with very few nutrients; even the best diet in the world cannot provide everything our cells need at the metabolic level (our biochemical nutrient requirements are greater than what we can get through food).

We live in such a toxic world, with such a fast-paced lifestyle, which generates so much stress that even the best diet in the world can't meet the needs of our bodies and minds.

And the same goes for supplementation; it's difficult to find quality supplements that aren't loaded with chemical excipients that can cause harm to your health and increase your toxic load.

Furthermore, it is difficult to find in a single product everything our liver needs to function fully, and thus be able to open all the detoxifying pathways such as those mentioned (phase I and phase II).

Until 3 years ago, whenever I had to establish a detox protocol through an orthomolecular therapy, I had to put together more than 6 different supplements, in order to offer the liver everything it needs to carry out its metabolic processes, in addition, these more than 6 supplements were “ALWAYS” loaded with harmful excipients, so there came a point where I decided to create a supplement that could have everything the liver needs to function fully, and also, without a harmful chemical excipient.

The result of more than 15 years of passion and research in orthomecular medicine has led me to create a revolutionary, innovative, and truly effective supplement, Energyprodetox.

Finally, a product that allows you to perform a REAL detox, and that in less than 4 months can scientifically quantify (with analytics) that what it offers becomes reality.

Hepatic biotransformation, hundreds of metabolic pathways involving countless enzymes and cofactors, which EnergyProdetox addresses from the first reaction to the last, opening the doors to the evacuation of toxic substances, and thus being able to say goodbye to all that toxic waste that was generating internal disturbance.

I invite you to discover a revolutionary supplement that will not only help you eliminate all toxins from your body, but also help you reach your peak physical and mental health.