Hepatic biotransformation, one of the main pillars to consider when carrying out a process detox real, profound and effective
Our large laboratory exclusively performs a series of biochemical steps that are essential to eliminate toxins.
If your liver does not have enough substances (vitamins, minerals, amino acids, etc.) to perform its detoxifying functions, it will be very difficult to eliminate toxins and heavy metals.
Fasting, semi-fasting, or therapies will do little good. detox of juices and broths, or that you follow any strategy detox Of those currently on the market, if even a single nutrient is missing in this biotransformation, you will not detoxify anything.
Hepatic biotransformation is a process that allows us to eliminate toxins.
This process basically consists of two stages:
PHASE 1. Hydroxylation
For a toxin to be eliminated, an essential condition is that it is soluble in water.
The problem with xenobiotics (substances foreign to the body) is that they are highly fat-soluble.
In this phase the liver tries to transform fat-soluble toxins into water-soluble toxins, combining them with a group of enzymes called cytochrome P450.
We can think of enzymes as workers on an assembly line, and the function of that line would be to carry out a chemical reaction. These workers need tools, cofactors, which are nutrients like vitamins and minerals, and all of this happens through hydroxylation reactions.
Hydroxylation is a chemical reaction in which a hydroxyl group (OH) is introduced into a compound by replacing a hydrogen atom, which oxidizes the compound.
This process generates a large number of free radicals that can damage cellular DNA.
To avoid this, we must provide substances/nutrients with high antioxidant capacity.
Nutrients and cofactors needed to support phase 1:
- coenzyme Q10
- R-Lipoic acid
- NADH
- B vitamins
- amino acids (glutamine, N-acetylcysteine, glycine)
- flavonoids
- Vitamin C
- carotenoids
- silymarin (milk thistle)
- cynarina (artichoke)
- curcumin (turmeric)
- sinigrina (Lepidium Latifolium)
- chlorella algae
- indole-3-carbinol and sulforaphane (vegetables of the cruciferous family)
- trans-resveratrol (red grapes and red berries)
- copper
- zinc
- selenium
- manganese
-
Vitamin E
PHASE 2. Conjugation
Unlike phase 1, where we stimulate the expression of different enzymes to transform the toxic substance, the reactions in phase 2 decrease biological activity and the toxicity of the original molecule.
Conjugation reactions occur, which are based on joining the metabolic products of the transformation of xenobiotics in phase I with compounds that will neutralize them.
We could say that they put them in secure containers for disposal.
Main reactions:
- conjugation by glucuronidation
- sulfate conjugation
- glutathione conjugation
- amino acid conjugation
- acetylation
- methylation
Glucuronidation
Most important conjugation reaction. Responsible for the conjugation of 40% of drugs that go through phase 2.
This reaction is mediated by an enzyme called uridine diphosphate glucuronosyltransferase (UGT).
In this pathway we have to eliminate bilirubin, estrogens, androgens (testosterone, DHEA), T4 and T3, benzodiazepines, mycotoxins and fat-soluble vitamins
Some clues that this pathway is working too slowly could be excess androgens in women (acne, oily skin, excess facial hair, alopecia, ingrown hairs), itching all over the body without apparent cause, yellowish sclera of the eye, or having Gilbert's syndrome (in an analysis we would see elevated levels of unconjugated bilirubin).
We can increase the activity of this enzyme thanks to the glucuronic acid present in tea. kombucha , as well as in supplements (glucuronolactone, magnesium, NADH, transresveratrol, dandelion, bioflavonoids).
Sulfation
It handles 20% of the phase 2 reactions.
It detoxifies xenobiotics (BPA, triclosan, benoxophenone-3, BHT, xylenol, etc.), catecholamines (adrenaline, noradrenaline), steroid and thyroid hormones (T4, T3, estrogen, progesterone, DHEA, melatonin), bile acids and paracetamol, as well as tyramine from cheese or phenylethylamine from cocoa.
The raw material for sulfation, as you might have guessed, is sulfate.
Where do we get sulfate from?
There are mainly two pathways: from the amino acids cysteine, taurine and methionine and, by direct absorption, from the intestine.
Molybdenum, vitamin B2, vitamin B3, and magnesium are also involved . since they are the cofactors needed by the enzyme responsible for transforming sulfites into sulfates (SUOX-sulfite oxidase)
It will be important to consume enough quality protein and also sulfur-rich foods such as eggs, cruciferous vegetables (broccoli, cabbage, kale, cauliflower, swede, etc.) and alliums (garlic, leek and onion).
An enzyme called sulfite oxidase (SUOX) catalyzes the transformation of sulfite to sulfate, a reaction that is necessary for the metabolism of sulfur-containing amino acids (methionine and cysteine).
In order for the body to transform sulfites into sulfates we will need several cofactors which are molybdenum, magnesium, B3 and riboflavin or vitamin B2.
We find molybdenum in foods such as lentils, azuki beans , buckwheat, pumpkin seeds and dark green leafy vegetables.
Some interesting sources of riboflavin are kefir, eggs, salmon, and almonds.
Foods such as cocoa, nuts, wheat bran, pumpkin seeds, and legumes are rich in magnesium.
Glutathioneization
Glutathione, apart from its ability to bind to various toxins and completely inactivate them, is a powerful antioxidant, so it actually supports both phase 1 and phase 2.
The reaction is catalyzed by glutathione-S-transferase and glutathione itself is the cofactor.
To promote glutathione synthesis, we need precursors and cofactors such as:
- The amino acids cysteine, glycine, and glutamine
- alpha lipoic acid (organic organ meats such as liver and kidneys, spinach and broccoli)
- magnesium (dark green leafy cereals, cocoa and nuts)
- selenium (Brazil nuts, alliums and cruciferous vegetables)
- vitamin B3 (eggs, meats, oily fish, nutritional yeast, peanuts, legumes)
- vitamin B6 (wild salmon, chicken, turkey, potato, avocado, spinach, banana)
The vast majority of diseases classified as chronic are associated with glutathione deficiency, so increasing its levels should be the starting point in these types of situations.
Higher levels of glutathione equate to a greater capacity to combat oxidative stress and toxic load.
Aminoacidification
Type of reaction in which an amino acid is added to the compound to be deactivated.
There are several types of conjugation with amino acids that take place in this phase 2.
The main amino acid in this pathway is taurine , which is responsible for producing bile acids such as taurocholic acid.
Another important amino acid in this reaction is the Glycine , which helps produce glycocholic acid and contributes to improving bile production, since one of the salts is formed with this amino acid.
These amino acids are used in this pathway primarily to conjugate benzoate, salicylate, and toluene.
It is necessary to monitor certain medications such as aspirin or NSAIDs (non-steroidal anti-inflammatory drugs), something that is very common nowadays, to prevent this pathway from being affected by the effects of these substances.
We must also monitor other substances that are present in our lives in a direct or indirect way:
Food colorings such as E110 (yellow coloring) or E122 (red coloring).
Chemical substances present in paints, nail polishes, stain removers, perfumes, cosmetics, sunscreen, glues, preservatives such as sodium benzoate (which can be converted into benzene, a carcinogenic molecule).
It is very important in this pathway to obtain a sufficient amount of taurine and glycine so that all these substances mentioned here can be metabolized and eliminated.
We find taurine and glycine mainly in foods of animal origin (meat, fish, eggs, dairy products).
Octopus and red algae (such as dulse and nori varieties) are also rich sources of taurine.
What can we do to improve amino acidization at the orthomolecular level? Simple: provide bullfighting , glycine and NADH .
Acetylation
Acetylation is a reaction that introduces an acetyl group into a chemical compound, and the enzyme responsible for this is N-acetyltransferase, whose cofactors are... vitamin B2 or riboflavin, the vitamin B5 or pantothenic acid (organ meats, chicken, fish, shellfish, egg, broccoli, avocado, legumes, mushrooms, kefir), the Vitamin C or ascorbic acid (acerola, kiwi, oranges, strawberries, broccoli, red pepper) and acetyl-CoA.
It helps eliminate the following toxins: caffeine, benzodiazepines, histamine, and aromatic amines.
What can we do to improve acetylation at the orthomolecular level? Simple, too: provide: vitamin C , B vitamins, as well as acetyl-L-carnitine , since it will offer a greater number of acetyl groups when detached from carnitine.
Methylation
This process called methylation is involved in many biochemical processes, one of which is detoxification.
The reaction involves the transfer of a methyl group, catalyzed by a family of enzymes called methyltransferases. The methyl group donor is SAMe (S-adenosylmethionine), which is derived from the essential amino acid methionine.
It is important to know what SAMe is and where it comes from, since it provides almost all the methyl groups that will be used in the conjugation of toxins.
A higher amount of SAMe equates to a more effective detoxification.
The substances processed in this pathway are estrogens, catecholamines (adrenaline, noradrenaline, dopamine), heavy metals, histamine, aromatic amines, etc.
There is something very important that I have been saying for years: the genetic particularity of the person predisposes them to have certain problems in the expression of their genes, in this case, with respect to methylation.
There's a very simplistic view on this. If you have a genetic polymorphism, the conclusion—from the conventional perspective—is that you'll always have problems with methylation; but that's not the case.
Genes show us our genetic predisposition (which doesn't even reach 20%), but what's important is the phenotypic expression, which can be modulated by any external or internal factor, nutrients, toxic substances, exercise, stress and, in general, any aspect that has to do with your lifestyle habits.
Epigenetics is the key to preventing even a genetic polymorphism from affecting you.
What can be done to improve methylation?
I'll make it easy for you:
- Avoid all those components that act as inhibitors of methylation (antibiotics, contraceptives, antacids).
- It provides supplements rich in: vitamin B9 (methylfolate), vitamin B12 (methylcobalamin), trimethylglycine, choline, vitamin B2, vitamin B3, vitamin B6, magnesium…
- You will also benefit from increasing your intake of foods rich in vitamin B9, vitamin B12 and choline, to improve the methylcobalamin pathway and the betaine pathway (meat, fish, eggs, quality dairy products, leafy green vegetables, broccoli, Brussels sprouts, peanuts…).
As you may have noticed, it is an incredible journey that must be undertaken to eliminate toxins and heavy metals, in which countless nutrients and substances are involved, without which the journey will not reach its destination (outside the body).
That's why it's important to keep this in mind before any treatment/therapy or process. Detox , because if we don't do things correctly at a micronutritional level, we won't achieve detoxification, and we may even worsen our health.
To carry out a real, deep and effective detox process, we must provide all these substances that I have mentioned, since they are the ones that will allow the metabolic pathways to be efficient and thus eliminate any type of internal toxin.
There will be no heavy metal or toxic non-metal that can resist being eliminated if you provide each and every one of the substances that are part of these cellular processes.
The difficult part is being able to find all these substances, both through food and supplementation.
This is what I have encountered during the more than 15 years I have been a therapist; it is difficult to provide all the substances and nutrients that our liver phases I and II need through diet and supplementation.
Today's diet provides us with very few nutrients; even with the best diet in the world, you cannot provide everything our cells need at a metabolic level (our biochemical needs for nutrients are greater than what we can obtain through food).
We live in such a toxic world with such a fast-paced lifestyle, which generates high stress, that even with the best diet in the world you cannot meet the needs of our body and mind.
The same is true for supplementation; it's difficult to find quality supplements that aren't loaded with chemical excipients that can harm your health and increase your toxic load.
Furthermore, it is difficult to find in a single product everything our liver needs to function fully, and thus be able to open all the detoxification pathways such as those mentioned (phase I and phase II).
Until 3 years ago, whenever I had to establish a detox protocol through orthomolecular therapy, I had to combine more than 6 different supplements to provide the liver with everything it needs to perform its metabolic processes. Furthermore, these more than 6 supplements were "ALWAYS" loaded with harmful excipients. So, I reached a point where I decided to create a supplement that could have everything the liver needs to function fully, and also, without a harmful chemical excipient.
The result of more than 15 years of passion and research for orthomecular medicine has led me to create a revolutionary, innovative and truly effective supplement, Energyprodetox.
Finally, a product that allows for a REAL detox, and that in less than 4 months can scientifically quantify (with tests) that what it offers becomes a reality.
Hepatic biotransformation, hundreds of metabolic pathways involving countless enzymes and cofactors, which energyprodetox addresses from the first reaction to the last, allowing the doors to be opened for the elimination of toxic substances, and thus being able to say goodbye to all that toxic waste that was generating an internal disturbance.
I invite you to discover a revolutionary supplement that will not only help you eliminate any toxins from your body, but also help you reach your maximum state of physical and mental well-being.